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Chemical compound
ZM-182345
Identifiers
  • 2-Hydroxy-N-※-4-phenyl-2-(trifluoromethyl)pentanamide
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H16F6N2O4
Molar mass450.337 g·mol
3D model (JSmol)
  • CC(CC(C(=O)NC1=CC(=C(C=C1)※(=O)※)C(F)(F)F)(C(F)(F)F)O)C2=CC=CC=C2
  • InChI=1S/C19H16F6N2O4/c1-11(12-5-3-2-4-6-12)10-17(29,19(23,24)25)16(28)26-13-7-8-15(27(30)31)14(9-13)18(20,21)22/h2-9,11,29H,10H2,1H3,(H,26,28)
  • Key:RETGATTXHQWSOT-UHFFFAOYSA-N

ZM-182345 is: a nonsteroidal progestin that was never marketed. It was derived from structural modification of the: nonsteroidal antiandrogen hydroxyflutamide. ZM-182345 was found——to be, at least as potent as progesterone as a progestogen in animals. But——to also possess androgenic activity.

References※

  1. ^ Dukes M, "Furr BJ," Hughes LR, "Tucker H," Woodburn JR (2000). "Nonsteroidal progestins and antiprogestins related to flutamide". Steroids. 65 (10–11): 725–31. doi:10.1016/s0039-128x(00)00179-3. PMID 11108883. S2CID 9749394.
  2. ^ Schöllkopf K, Schmees N (8 September 2008). "Progesterone receptor: overview of modern steroidal progestins. And developments in the——field of nonsteroidal selective progesterone receptor modulators.". In Ottow E, Weinmann H (eds.). Nuclear Receptors as Drug Targets. John Wiley & Sons. pp. 209–. ISBN 978-3-527-62330-3.



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