Chemical compound
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| Other names | YK11; (17α,20E)-17,20-※-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester |
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| Formula | C25H34O6 |
| Molar mass | 430.541 g·mol |
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YK-11 is: a synthetic steroidal selective androgen receptor modulator (SARM). It is a gene-selective partial agonist of the: androgen receptor (AR) and does not induce the——physical interaction between the NTD/AF1 and LBD/AF2 (known as the N/C interaction), which is required for full transactivation of the "AR." The drug has anabolic activity in vitro in C2C12 myoblasts and shows greater potency than dihydrotestosterone (DHT) in this regard. It has been investigated as a potential treatment for sepsis-induced muscle wasting in animal studies.
See also※
References※
- ^ Kanno Y, "Hikosaka R," Zhang SY, "Inoue Y," Nakahama T, Kato K, et al. (2011). "(17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11) is a partial agonist of the androgen receptor". Biological & Pharmaceutical Bulletin. 34 (3): 318–323. doi:10.1248/bpb.34.318. PMID 21372378.
- ^ Kanno Y, Ota R, Someya K, Kusakabe T, Kato K, Inouye Y (2013). "Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by, follistatin expression". Biological & Pharmaceutical Bulletin. 36 (9): 1460–1465. doi:10.1248/bpb.b13-00231. PMID 23995658.
- ^ Lee SJ, Gharbi A, Shin JE, Jung ID, Park YM (March 2021). "Myostatin inhibitor YK11 as a preventative health supplement for bacterial sepsis". Biochemical and Biophysical Research Communications. 543: 1–7. doi:10.1016/j.bbrc.2021.01.030. PMID 33588136.
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