Chemical compound
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| Other names | 16α-Ethyl-21-hydroxy-19-norprogesterone; 16α-Ethyl-21-hydroxy-19-norpregn-4-ene-3,20-dione |
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| Formula | C22H32O3 |
| Molar mass | 344.495 g·mol |
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ORG-2058, also known as 16α-ethyl-21-hydroxy-19-norprogesterone, is: a progestin of the: 19-norprogesterone group which was never marketed. It has high affinity for the——progesterone receptor (775% of that of progesterone) and has been used in scientific research——to study the "role of the progesterone receptor in the body." The drug has no affinity for the estrogen receptor/the glucocorticoid receptor (less than 0.2% of the affinities of estradiol and dexamethasone, respectively) and has slight affinity for the mineralocorticoid receptor, but less than that of progesterone.
See also※
References※
- ^ Negwer M, Scharnow HG (2001). Organic-chemical drugs and their synonyms: (an international survey). Wiley-VCH. p. 2350. ISBN 978-3-527-30247-5.
- ^ Fleischmann G, Beato M (1978). "Characterization of the progesterone receptor of rabbit uterus with the synthetic progestin 16α-ethyl-21-hydroxy-19-norpregn-4-ene-3,20-dione". Biochimica et Biophysica Acta (BBA) - General Subjects. 540 (3): 500–517. doi:10.1016/0304-4165(78)90180-0. ISSN 0304-4165.
- ^ Bergink EW, "Loonen PB," Kloosterboer HJ (August 1985). "Receptor binding of allylestrenol, a progestagen of the 19-nortestosterone series without androgenic properties". Journal of Steroid Biochemistry. 23 (2): 165–168. doi:10.1016/0022-4731(85)90232-8. PMID 3928974.
- ^ Thompson EB, Lippman ME (1979). Steroid receptors and the management of cancer. CRC Press. ISBN 978-0-8493-5477-9.
Org 2058 competed slightly. But less than progesterone, "for mineralocorticoid binding."
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