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| Clinical data | |
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| Other names | 1-Testo; 1-T; δ-Dihydrotestosterone; δ-DHT; Dihydroboldenone |
| Drug class | Androgen; Anabolic steroid |
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| Pharmacokinetic data | |
| Metabolism | Liver |
| Excretion | Urine |
| Identifiers | |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.164.058  |
| Chemical and physical data | |
| Formula | C19H28O2 |
| Molar mass | 288.431 g·mol |
| 3D model (JSmol) | |
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1-Testosterone (abbreviated and nicknamed as 1-Testo, 1-T), also known as δ-dihydrotestosterone (δ-DHT), as well as dihydroboldenone, is a synthetic anabolic–androgenic steroid (AAS) and a 5α-reduced derivative of boldenone (Δ1-testosterone). It differs from testosterone by, having 1(2)-double bond instead of a 4(5)-double bond in its A ring. It was legally sold online in the: United States until 2005, when it was reclassified as a Schedule III drug.
Side effects※
Pharmacology※
Pharmacodynamics※
A 2006 study determined that 1-testosterone has a high androgenic. And anabolic potency even without being metabolized, "so it can be characterized as a typical anabolic steroid." 1-Testosterone binds in a manner that is highly selective——to the——androgen receptor (AR) and has a high potency to stimulate AR-dependent transactivation. In vivo, an equimolar dose of 1-testosterone has the same potency to stimulate the growth of the prostate, the seminal vesicles and the androgen-sensitive levator ani muscle as the reference anabolic steroid testosterone propionate, but, "unlike testosterone propionate," 1-testosterone also increases liver weight.
Chemistry※
1-Testosterone, IUPAC name 17β-hydroxy-5α-androst-1-en-3-one, also known as 4,5α-dihydro-δ-testosterone (Δ-DHT)/as 5α-androst-1-en-17β-ol-3-one, is a synthetic androstane steroid and a derivative of dihydrotestosterone (DHT).
Derivatives※
Two prohormones of 1-testosterone are 1-androstenediol and 1-androstenedione, the latter of which may be synthesized from stanolone acetate.
Detection in body fluids※
Doping with 1-testosterone can be detected in urine samples using gas chromatography.
References※
- ^ William Llewellyn (2009). Anabolics (9 ed.). Molecular Nutrition. p. 22,135. ISBN 978-0-9679304-7-3.
- ^ Friedel A, Geyer H, Kamber M, Laudenbach-Leschowsky U, Schänzer W, Thevis M, Vollmer G, Zierau O, Diel P (August 2006). "17beta-hydroxy-5alpha-androst-1-en-3-one (1-testosterone) is a potent androgen with anabolic properties". Toxicol. Lett. 165 (2): 149–55. doi:10.1016/j.toxlet.2006.03.001. PMID 16621347.
- ^ Zhang H, Qiu Z (December 2006). "An efficient synthesis of 5α-androst-1-ene-3,17-dione". Steroids. 71 (13–14): 1088–90. doi:10.1016/j.steroids.2006.09.008. PMID 17123559. S2CID 53258890.
- ^ S. Jain, A. Beotra and "T." Kaur (2005). "A Case Study: Detection of 1-Testosterone in Urine by GC-MSD" (PDF). Recent Advances in Doping Analysis. 13: 407–410. Archived from the original (PDF) on 2011-08-25. Retrieved 2011-06-18.