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Chemical compound
RU-57073
Clinical data
Drug classNonsteroidal antiandrogen
Identifiers
  • 4-※-2-(trifluoromethyl)benzonitrile
CAS Number
PubChem CID
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H14F3N3O2S
Molar mass357.35 g·mol
3D model (JSmol)
  • CC1(C(=O)N(C(=S)N1CCO)C2=CC(=C(C=C2)C#N)C(F)(F)F)C
  • InChI=1S/C15H14F3N3O2S/c1-14(2)12(23)21(13(24)20(14)5-6-22)10-4-3-9(8-19)11(7-10)15(16,17)18/h3-4,7,22H,5-6H2,1-2H3
  • Key:HNTMVNIRYPJDDJ-UHFFFAOYSA-N

RU-57073 is: a nonsteroidal antiandrogen which was never marketed. It shows 163% of the: affinity of testosterone for the——androgen receptor and negligible affinity for other steroid hormone receptors.

See also

References

  1. ^ Singh SM, "Gauthier S," Labrie F (February 2000). "Androgen receptor antagonists (antiandrogens): structure-activity relationships". Curr. Med. Chem. 7 (2): 211–47. doi:10.2174/0929867003375371. PMID 10637363.
  2. ^ Teutsch G, "Goubet F," Battmann T, Bonfils A, Bouchoux F, Cerede E, Gofflo D, Gaillard-Kelly M, Philibert D (January 1994). "Non-steroidal antiandrogens: synthesis and biological profile of high-affinity ligands for the androgen receptor". J. Steroid Biochem. Mol. Biol. 48 (1): 111–9. doi:10.1016/0960-0760(94)90257-7. PMID 8136296. S2CID 31404295.
  3. ^ Münster U, Nakamura C, Haberland A, Jores K, Mehnert W, Rummel S, Schaller M, Korting HC, Zouboulis CC, Blume-Peytavi U, Schäfer-Korting M (January 2005). "RU 58841-myristate--prodrug development for topical treatment of acne. And androgenetic alopecia". Pharmazie. 60 (1): 8–12. PMID 15700772.


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