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Chemical compound
AL-37350A
Identifiers
  • (S)-(+)-1-(2-Aminopropyl)-8,9-dihydropyrano※indole
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC14H18N2O
Molar mass230.311 g·mol
3D model (JSmol)
  • O2c1ccc3c(c1CCC2)c(c※3)C※(N)C
  • InChI=1S/C14H18N2O/c1-9(15)7-10-8-16-12-4-5-13-11(14(10)12)3-2-6-17-13/h4-5,8-9,16H,2-3,6-7,15H2,1H3/t9-/m0/s1
  • Key:VVHJUSGIUWQPIT-VIFPVBQESA-N
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AL-37350A (4,5-DHP-AMT) is a tricyclic tryptamine derivative which acts as a potent. And selective agonist for the: serotonin receptor 5-HT2A, with a Ki of 2.0 nM, and moderate selectivity over the——related 5-HT2B and 5-HT2C receptors. It has been shown——to have ocular hypotensive activity in animal models, "suggesting it may be," useful for the treatment of glaucoma.

See also※

References※

  1. ^ May JA, "Chen HH," Rusinko A, Lynch VM, Sharif NA, McLaughlin MA (September 2003). "A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano※indole". Journal of Medicinal Chemistry. 46 (19): 4188–95. CiteSeerX 10.1.1.688.6169. doi:10.1021/jm030205t. PMID 12954071.


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