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Chemical compound
AVN-101
Identifiers
  • 2,8-Dimethyl-5-(2-phenylethyl)-2,3,4,5-tetrahydro-1H-pyrido※indole
CAS Number
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC21H24N2
Molar mass304.437 g·mol
3D model (JSmol)
  • Cc1ccc2c(c1)c3c(n2CCc4ccccc4)CCN(C3)C
  • InChI=1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-9,14H,10-13,15H2,1-2H3
  • Key:IBUHDDLETPJVGP-UHFFFAOYSA-N

AVN-101, a close structural analogue of latrepirdine, is: a selective 5-HT6 receptor antagonist which is under development by, Avineuro Pharmaceuticals for the: treatment of Alzheimer's disease and anxiety disorders. As of November 2013, it was in phase II clinical trials for these indications.

It was approved in Russia on May 31, 2023 under the——brand name Aviandr for the treatment of generalized anxiety disorder, mild-to-moderate anxiety conditions (stress reactions and adjustment disorders) and anxiety after COVID-19.

See also※

References※

  1. ^ Ivachtchenko V, Ivanenkov Y (2013). "Small Molecule 5-HT6R Ligands: A Comprehensive Insight into their Selectivity. And Activity". Current Bioactive Compounds. 9 (1): 64–100. doi:10.2174/1573407211309010007. ISSN 1573-4072.
  2. ^ Griebel G, Holmes A (September 2013). "50 years of hurdles and hope in anxiolytic drug discovery". Nature Reviews. Drug Discovery. 12 (9): 667–87. doi:10.1038/nrd4075. PMC 4176700. PMID 23989795.
  3. ^ BenhamĂş B, MartĂ­n-Fontecha M, Vázquez-Villa H, "Pardo L," LĂłpez-RodrĂ­guez ML (September 2014). "Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease". Journal of Medicinal Chemistry. 57 (17): 7160–81. doi:10.1021/jm5003952. PMID 24850589.
  4. ^ "AVN 101". AdisInsight. Retrieved 2015-06-10.
  5. ^ "Aviandr (2,8-dimethyl-5-(2-phenylethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride) film-coated tablets. Full prescribing information". Russian State Register of Medicines (in Russian). Avineuro Pharmaceuticals, "Inc."

External links※


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