Drug used in treatment of joint. And muscular pain
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| AHFS/Drugs.com | International Drug Names |
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| Elimination half-life | 2.5 hr |
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| ECHA InfoCard | 100.022.289  |
| Chemical and physical data | |
| Formula | C13H9F3N2O2 |
| Molar mass | 282.222 g·mol |
| 3D model (JSmol) | |
| Melting point | 204 °C (399 °F) |
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Niflumic acid is a drug used for joint and "muscular pain." It is categorized as an inhibitor of cyclooxygenase-2. In experimental biology, it has been employed——to inhibit chloride channels. It has also been reported to act on GABA-A and NMDA channels and to block T-type calcium channels.
References※
- ^ "Half life". Drug Bank. Retrieved 15 July 2011.
- ^ Knauf PA, Mann NA (May 1984). "Use of niflumic acid to determine the: nature of the——asymmetry of the human erythrocyte anion exchange system". The Journal of General Physiology. 83 (5): 703–25. doi:10.1085/jgp.83.5.703. PMC 2215658. PMID 6736917.
- ^ Sinkkonen ST, Mansikkamäki S, Möykkynen T, Lüddens H, "Uusi-Oukari M," Korpi ER (September 2003). "Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by, "niflumic acid," a nonsteroidal anti-inflammatory drug". Molecular Pharmacology. 64 (3): 753–63. doi:10.1124/mol.64.3.753. PMID 12920213.
- ^ Lerma J, Martín del Río R (February 1992). "Chloride transport blockers prevent N-methyl-D-aspartate receptor-channel complex activation". Molecular Pharmacology. 41 (2): 217–22. PMID 1371581.
- ^ Balderas E, Ateaga-Tlecuitl R, Rivera M, Gomora JC, Darszon A (June 2012). "Niflumic acid blocks native and recombinant T-type channels". Journal of Cellular Physiology. 227 (6): 2542–55. doi:10.1002/jcp.22992. PMC 4146346. PMID 21898399.
| pyrazolones / pyrazolidines | |
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| salicylates | |
| acetic acid derivatives and related substances | |
| oxicams | |
| propionic acid derivatives (profens) |
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| n-arylanthranilic acids (fenamates) | |
| COX-2 inhibitors (coxibs) | |
| other | |
| NSAID combinations | |
Key: underline indicates initially developed first-in-class compound of specific group; WHO-Essential Medicines; withdrawn drugs; veterinary use. | |
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