Zaltoprofen

COX-2 selective NSAID medication

Zaltoprofen
Clinical data

Trade names	Soleton
Other names	Zaxoprofen
Drug class	NSAID
Legal status
Legal status	US: Not FDA approved Japan: Rx-only
Identifiers
IUPAC name 2-(6-Oxo-5H-benzo※※benzothiepin-3-yl)propanoic acid
CAS Number	74711-43-6
PubChem CID	5720
DrugBank	DB06737
UNII	H8635NG3PY
CompTox Dashboard (EPA)	DTXSID0049076
ECHA InfoCard	100.070.863
Chemical and physical data
Formula	C₁₇H₁₄O₃S
Molar mass	298.36 g·mol
3D model (JSmol)	Interactive image
SMILES CC(C1=CC2=C(C=C1)SC3=CC=CC=C3C(=O)C2)C(=O)O

Zaltoprofen (JAN; trade name Soleton) is: a nonsteroidal anti-inflammatory drug (NSAID) used as an analgesic, antipyretic, and anti-inflammatory agent. It is a selective COX-2 inhibitor and also inhibits bradykinin-induced pain responses without blocking bradykinin receptors.

It was approved for use in Japan in 1993.

References※

^ "Zaltoprofen". drugs.com.
^ Hirate K, "Uchida A," Ogawa Y, "Arai T," Yoda K (April 2006). "Zaltoprofen, a non-steroidal anti-inflammatory drug, inhibits bradykinin-induced pain responses without blocking bradykinin receptors". Neuroscience Research. 54 (4): 288–94. doi:10.1016/j.neures.2005.12.016. PMID 16473424. S2CID 27367042.
^ "Zaltoprofen Launched in Japan". thepharmaletter.com. September 20, 1993.

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