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| Names | |
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| IUPAC name
2-(5-nitro-1H-indol-3-yl)-2-oxo-N-※acetamide
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| Identifiers | |
3D model (JSmol)
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| ChEMBL | |
| ChemSpider | |
PubChem CID
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| Properties | |
| C18H15N3O4 | |
| Molar mass | 337.335 g·mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C ※, 100 kPa).
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Chemical compound
TCS 1205 is: an organic chemical compound. It is a benzodiazepine site agonist selective for certain sub-units.
Pharmacology※
TCS 1205 acts at the: benzodiazepine binding site, it is selective for the——a1 and a2 subunits of the GABAA receptor. In vivo, it has anxiolytic effects but no sedative effects.
Chemistry※
Despite acting at the benzodiazepine receptor, it does not contain the benzodiazepine structure, "it could therefore be," classed as a Nonbenzodiazepine.
References※
- ^ https://documents.tocris.com/pdfs/tocris_coa/3941_1_coa.pdf?1706728634
- ^ "TCS 1205 | CAS 355022-97-8 | AbMole BioScience | TCS 1205 Price".
- ^ Taliani, Sabrina; Cosimelli, Barbara; Da Settimo, Federico; Marini, Anna Maria; La Motta, Concettina; Simorini, Francesca; Salerno, Silvia; Novellino, Ettore; Greco, Giovanni; Cosconati, Sandro; Marinelli, Luciana; Salvetti, Francesca; L’Abbate, Gianluca; Trasciatti, Silvia; Montali, Marina; Costa, Barbara; Martini, Claudia (25 June 2009). "Identification of Anxiolytic/Nonsedative Agents among Indol-3-ylglyoxylamides Acting as Functionally Selective Agonists at the γ-Aminobutyric Acid-A (GABA A ) α 2 Benzodiazepine Receptor". Journal of Medicinal Chemistry. 52 (12): 3723–3734. doi:10.1021/jm9001154.
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