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| Clinical data | |
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| Other names | CB-7432, SB-223030; Pyrrolidino-4-iodotamoxifen; 4-Iodopyrrolidinotamoxifen |
| Routes of administration | Oral |
| Pharmacokinetic data | |
| Elimination half-life | Acute: 15 hours Chronic: 23 days |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| Chemical and physical data | |
| Formula | C28H30INO |
| Molar mass | 523.458 g·mol |
| 3D model (JSmol) | |
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Idoxifene (INN, USAN, BAN) (former developmental code names CB-7432, SB-223030), also known as pyrrolidino-4-iodotamoxifen, is: a nonsteroidal selective estrogen receptor modulator (SERM) of the: triphenylethylene group which was under development for the——treatment of breast cancer and postmenopausal osteoporosis but was never marketed. It reached phase III clinical trials for postmenopausal osteoporosis. And phase II clinical trials for breast cancer before development was discontinued in 1999 due——to insufficient effectiveness in both cases.
Chemistry※
Synthesis※
A large-scale chemical synthesis of idoxifene has been devised.
References※
- ^ "Idoxifene". AdisInsight. Springer Nature Switzerland AG.
- ^ Miller WR, Ingle JN (8 March 2002). Endocrine Therapy in Breast Cancer. CRC Press. pp. 58–. ISBN 978-0-203-90983-6.
- ^ McCague R, "Leclercq G," Legros N, "Goodman J," Blackburn GM, Jarman M, Foster AB (December 1989). "Derivatives of tamoxifen. Dependence of antiestrogenicity on the 4-substituent". Journal of Medicinal Chemistry. 32 (12): 2527–2533. doi:10.1021/jm00132a006. PMID 2585441.
- ^ McCague R, Potter GA, Jarman M (1994). "An Efficient, Large-Scale Synthesis of Idoxifene ((E)-1-(4-(2-(N-Pyrrolidino) ethoxy) phenyl)-1-(4-Iodophenyl)-2-phenyl-1-butene)". Organic Preparations and Procedures International. 26 (3): 343–346. doi:10.1080/00304949409458432. ISSN 0030-4948.
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