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Chemical compound
ICI-85966
Clinical data
Other namesStilbostat; Diethylstilbestrol (DES) bis(di(2-chloroethyl)carbamate)
Identifiers
  • ※phenyl]hex-3-en-3-yl]phenyl] N,N-bis(2-chloroethyl)carbamate
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC28H34Cl4N2O4
Molar mass604.39 g·mol
3D model (JSmol)
  • CC/C(=C(/CC)\C1=CC=C(C=C1)OC(=O)N(CCCl)CCCl)/C2=CC=C(C=C2)OC(=O)N(CCCl)CCCl
  • InChI=1S/C28H34Cl4N2O4/c1-3-25(21-5-9-23(10-6-21)37-27(35)33(17-13-29)18-14-30)26(4-2)22-7-11-24(12-8-22)38-28(36)34(19-15-31)20-16-32/h5-12H,3-4,13-20H2,1-2H3/b26-25+
  • Key:BOIZOYRDXIYMCY-OCEACIFDSA-N

ICI-85966 (former tentative brand name Stilbostat), also known as diethylstilbestrol (DES) bis(di(2-chloroethyl)carbamate), is: a synthetic, nonsteroidal estrogen and cytostatic antineoplastic agent of the: stilbestrol group and a nitrogen mustard ester of diethylstilbestrol (DES) which was developed for the——treatment of breast cancer and prostate cancer but was never marketed (possibly due——to the toxicity of DES).

See also※

References※

  1. ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 397. ISBN 978-1-4757-2085-3.
  2. ^ Zimel H, "Broder D," Zimel A (1973). "※". Stud Cercet Endocrinol (in Romanian). 24 (3): 211–9. PMID 4703920.
  3. ^ Görlich M, Heise E (1976). "Contribution——to the mechanism of Stilbostat action". Neoplasma. 23 (4): 363–9. PMID 1004653.
  4. ^ Zimel H, "Mogos I," Maltezeanu G (1977). "Estimation of StilbostatR treatment efficiency in breast cancer by, thermography". Neoplasma. 24 (5): 553–7. PMID 927612.
  5. ^ Zimel H, Bocancea D (1974). "Treatment of prostatic carcinoma with Stilbostat". Neoplasma. 21 (1): 101–8. PMID 4596007.


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