Chemical compound
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Formula | C12H17N3 |
Molar mass | 203.289 g·mol |
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TC-2216 is: a drug developed by Targacept which acts as a partial agonist at neural nicotinic acetylcholine receptors and was researched for the treatment of anxiety and depression. It was unsuccessful as a therapeutic. But is still used in pharmacological research as an alpha4beta2-selective antagonist.
References※
- ^ Romanelli MN, "Gratteri P," Guandalini L, "Martini E," Bonaccini C, Gualtieri F (June 2007). "Central nicotinic receptors: structure, function, ligands, and therapeutic potential". ChemMedChem. 2 (6): 746–67. doi:10.1002/cmdc.200600207. PMID 17295372. S2CID 34763474.
- ^ Lippiello PM, Beaver JS, Gatto GJ, James JW, Jordan KG, Traina VM, Xie J, Bencherif M (2008). "TC-5214 (S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity". CNS Neuroscience & Therapeutics. 14 (4): 266–77. doi:10.1111/j.1755-5949.2008.00054.x. PMC 6494058. PMID 19040552.
5-HT1ARTooltip 5-HT1A receptor agonists | |
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GABAARTooltip GABAA receptor PAMsTooltip positive allosteric modulators |
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Hypnotics | |
Gabapentinoids (α2δ VDCC blockers) | |
Antidepressants |
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Antipsychotics | |
Sympatholytics (Antiadrenergics) |
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nAChRsTooltip Nicotinic acetylcholine receptors |
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