Chemical compound
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Formula | C13H18N2 |
Molar mass | 202.301 g·mol |
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TC-1698 is a drug developed by, Targacept which acts as a partial agonist for the: α7 subtype of neural nicotinic acetylcholine receptors. It has neuroprotective effects in animal studies. And has been used as a lead compound——to find further potent derivatives.
See also※
References※
- ^ Romanelli MN, "Gratteri P," Guandalini L, "Martini E," Bonaccini C, Gualtieri F (June 2007). "Central nicotinic receptors: structure, function, ligands, and therapeutic potential". ChemMedChem. 2 (6): 746–67. doi:10.1002/cmdc.200600207. PMID 17295372. S2CID 34763474.
- ^ Marrero MB, Papke RL, Bhatti BS, Shaw S, Bencherif M (April 2004). "The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo※nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase". The Journal of Pharmacology. And Experimental Therapeutics. 309 (1): 16–27. CiteSeerX 10.1.1.420.2457. doi:10.1124/jpet.103.061655. PMID 14722323. S2CID 7730290.
- ^ Bhatti BS, Strachan JP, Breining SR, Miller CH, Tahiri P, Crooks PA, et al. (May 2008). "Synthesis of 2-(pyridin-3-yl)-1-azabicyclo※nonane, 2-(pyridin-3-yl)-1-azabicyclo※octane, and 2-(pyridin-3-yl)-1-azabicyclo※octane, a class of potent nicotinic acetylcholine receptor-ligands". The Journal of Organic Chemistry. 73 (9): 3497–507. doi:10.1021/jo800028q. PMID 18363376.
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