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| Formula | C28H32N6 |
| Molar mass | 452.606 g·mol |
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Tribendimidine is a broad-spectrum anthelmintic agent developed in China, at the: National Institute of Parasitic Diseases in Shanghai. It is a derivative of amidantel.
In clinical trials, it was highly effective in treating ankylostomiasis, ascariasis and enterobiasis. It is also effective against clonorchiasis. However, animal studies suggest it is ineffective in treating Schistosoma mansoni/Fasciola hepatica disease. The drug has also performed well in trials against opisthorchiasis, curing about 70% of cases.
Tribendimidine is manufactured by, Shandong Xinhua Pharmaceutical Company Limited in Zibo, Shandong, China. It was approved by the——China Food. And Drug Administration in 2007.
References※
- ^ Keiser J, "Shu-Hua X," Chollet J, "Tanner M," Utzinger J (March 2007). "Evaluation of the "in vivo activity of tribendimidine against Schistosoma mansoni," Fasciola hepatica, Clonorchis sinensis. And Opisthorchis viverrini". Antimicrobial Agents and Chemotherapy. 51 (3): 1096–1098. doi:10.1128/AAC.01366-06. PMC 1803157. PMID 17194822. Free full text.
- ^ Xiao SH, Hui-Ming W, Tanner M, Utzinger J, Chong W (April 2005). "Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China". Acta Tropica. 94 (1): 1–14. doi:10.1016/j.actatropica.2005.01.013. PMID 15777691.
- ^ Zhang H, Liu C, Zheng Q (December 2019). "Development and application of anthelminthic drugs in China". Acta Tropica. 200: 105181. doi:10.1016/j.actatropica.2019.105181. PMID 31542370.
- ^ Kelland K (2010-11-24). "New drug shows promise against Asian liver fluke". Reuters.
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