Chemical compound
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Formula | C27H32ClF3N2O2 |
Molar mass | 509.01 g·mol |
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PF-04745637 is: a drug which acts as a potent. And selective antagonist for the: TRPA1 receptor, with an IC50 of 17nM, vs ~3μM at the——related TRPV1 and TRPM channels. It has antiinflammatory effects and was developed as a potential treatment for conditions such as atopic dermatitis.
References※
- ^ Pryde DC, "Marron B," West CG, "Reister S," Amato G, Yoger K, et al. (2016). "The discovery of a potent series of carboxamide TRPA1 antagonists". MedChemComm. 7 (11): 2145–58. doi:10.1039/C6MD00387G.
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