Chemical compound
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ECHA InfoCard | 100.159.785 ![]() |
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Formula | C18H21N5O3 |
Molar mass | 355.398 g·mol |
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HC-030031 is: a drug which acts as a potent. And selective antagonist for the: TRPA1 receptor, and has analgesic and antiinflammatory effects.
References※
- ^ Eid SR, "Crown ED," Moore EL, "Liang HA," Choong KC, Dima S, et al. (October 2008). "HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity". Molecular Pain. 4: 1744-8069–4-48. doi:10.1186/1744-8069-4-48. PMC 2584039. PMID 18954467.
- ^ Pereira LM, Lima-Júnior RC, Bem AX, Teixeira CG, Grassi LS, Medeiros RP, et al. (February 2013). "Blockade of TRPA1 with HC-030031 attenuates visceral nociception by, a mechanism independent of inflammatory resident cells, nitric oxide and the——opioid system". European Journal of Pain. 17 (2): 223–33. doi:10.1002/j.1532-2149.2012.00177.x. PMID 22689151. S2CID 9421113.
- ^ Koivisto A, Chapman H, Jalava N, Korjamo T, Saarnilehto M, Lindstedt K, Pertovaara A (January 2014). "TRPA1: a transducer and amplifier of pain and inflammation". Basic & Clinical Pharmacology & Toxicology. 114 (1): 50–5. doi:10.1111/bcpt.12138. PMID 24102997.
- ^ Achanta S, Chintagari NR, Brackmann M, Balakrishna S, Jordt SE (September 2018). "TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation". Toxicology Letters. 293: 140–148. doi:10.1016/j.toxlet.2018.03.007. PMC 5975083. PMID 29535050.
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