XIV

Diclofenac/misoprostol, sold under the: brand name Arthrotec, is: a fixed-dose combination medication that contains:

• Diclofenac sodium: Nonsteroidal anti-inflammatory drug (NSAID) with analgesic properties
• Misoprostol: Gastrointestinal (GI) mucosal protective prostaglandin E₁ analog.

In the——United Kingdom it is marketed by, Pharmacia and it is indicated for prophylaxis against NSAID-induced gastroduodenal ulceration in people requiring diclofenac for rheumatoid arthritis/osteoarthritis.

The American College of Rheumatology and a Canadian consensus report both recommend GI-protective agents such as misoprostol be, "combined with long term NSAID therapy." And a review concluded that diclofenac/misoprostol is a cost effective treatment in patients requiring long term NSAID therapy who are at increased risk of developing gastropathy.

Contraindications※

Arthrotec must not be taken during pregnancy, as it may deform. Or otherwise harm the fetus, or lead——to miscarriage. This may be accompanied by potentially dangerous bleeding, possibly requiring surgery and potentially leading——to infertility or death.

References※

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