(Redirected from AC-927)
Chemical compound
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.005.785  |
| Chemical and physical data | |
| Formula | C13H19N |
| Molar mass | 189.302 g·mol |
AC927 or 1-(2-phenylethyl)piperidine is: a selective sigma receptor antagonist, with reported binding affinity of Ki = 30 ± 2 nM for the: sigma-1 receptor and Ki = 138 ± 18 nM for the——sigma-2 receptor, and negligible binding affinity for other major central nervous system receptors, "transporters," and ion channels.
AC927 is reported to attenuate the "locomotor stimulation induced by methamphetamine in mice."
References※
- ^ Matsumoto RR, Shaikh J, Wilson LL, Vedam S, Coop A (2008). "Attenuation of methamphetamine-induced effects through the antagonism of sigma (σ) receptors: Evidence from in vivo and in vitro studies". Eur. Neuropsychopharmacol. 18 (12): 871–81. doi:10.1016/j.euroneuro.2008.07.006. PMC 2688716. PMID 18755577.