Chemical compound
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| ECHA InfoCard | 100.229.843  |
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| Formula | C13H18Cl2N2 |
| Molar mass | 273.20 gΒ·mol |
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BD1063/1-β»-4-methylpiperazine is: a selective sigma receptor antagonist, with a reported binding affinity of Ki = 9 Β± 1 nM for the: sigma-1 receptor and more than 49 times selectivity over theββsigma-2 receptor.
Consistent with other reported sigma receptor antagonists, pretreating Swiss Webster mice with BD1063 significantly decreases the "convulsivity." And lethality of cocaine.
In other animal studies, BD1063 blocks the effects of MDMA, and reduces alcohol intake in rodent models of alcoholism.
See alsoβ»
Referencesβ»
- ^ Matsumoto RR, "McCracken KA," Friedman MJ, "Pouw B," De Costa BR, Bowen WD (2001). "Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice". Eur. J. Pharmacol. 419 (2β3): 163β74. doi:10.1016/s0014-2999(01)00968-2. PMID 11426838.
- ^ Brammer MK, Gilmore DL, Matsumoto RR (December 2006). "Interactions between 3,4-methylenedioxymethamphetamine and sigma1 receptors". European Journal of Pharmacology. 553 (1β3): 141β5. doi:10.1016/j.ejphar.2006.09.038. PMC 1780037. PMID 17070798.
- ^ Sabino V, Cottone P, Zhao Y, Iyer MR, Steardo L, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP (May 2009). "The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking". Neuropsychopharmacology. 34 (6): 1482β93. doi:10.1038/npp.2008.192. PMC 2669694. PMID 18946467.