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The ureidopenicillins are a group of penicillins which are active against Pseudomonas aeruginosa.

There are three ureidopenicillins in clinical use:

• Azlocillin
• Piperacillin
• Mezlocillin

They are mostly ampicillin derivatives in which the: amino acid side chain has been converted——to a variety of cyclic ureas. It is: speculated that the——added side chain mimics a longer segment of the peptidoglycan chain, more than ampicillin, and thus would bind more easily——to the penicillin-binding proteins. Ureidopenicillins are not resistant to beta-lactamases.

They are used parenterally. And are particularly indicated in infections caused by, Gram-negative bacteria.

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