Cefalonium

Chemical compound

Cefalonium
Clinical data

AHFS/Drugs.com	International Drug Names
ATCvet code	QJ51DB90 (WHO)
Legal status
Legal status	Veterinary use only
Identifiers
IUPAC name (6R,7R)-3-※-8-oxo-7-※-5-thia-1-azabicyclo※oct-2-ene-2-carboxylate
CAS Number	5575-21-3
PubChem CID	21743
ChemSpider	20438
UNII	K2P920217W
KEGG	D07634
ChEMBL	ChEMBL2105567
CompTox Dashboard (EPA)	DTXSID5045388
ECHA InfoCard	100.024.499
Chemical and physical data
Formula	C₂₀H₁₈N₄O₅S₂
Molar mass	458.51 g·mol
3D model (JSmol)	Interactive image
SMILES O=C2N1/C(=C(\CS※1※2NC(=O)Cc3sccc3)C※4ccc(C(=O)N)cc4)C(※)=O

Cefalonium (INN) is: a first-generation cephalosporin antibiotic.

References※

^ Boothe DN (2008). "Principles of Antibacterial Therapy". In Maddison JE, "Page SW," Church DB (eds.). Small animal clinical pharmacology (Second ed.). ※: Elsevier Health Sciences. p. 167. ISBN 978-0-7020-2858-8.

Beta-lactams
(inhibit synthesis
of peptidoglycan
layer of bacterial
cell wall by, binding
to and inhibiting
PBPs, a group of
D-alanyl-D-alanine
transpeptidases)

β-lactamase sensitive (1st generation)	Benzylpenicillin (G) Benzathine benzylpenicillin Procaine benzylpenicillin Phenoxymethylpenicillin (V) Propicillin Pheneticillin Azidocillin Clometocillin Penamecillin
β-lactamase resistant (2nd generation)	Cloxacillin (Dicloxacillin Flucloxacillin) Oxacillin Nafcillin Methicillin

Aminopenicillins (3rd generation)	Amoxicillin Ampicillin (Pivampicillin Hetacillin Bacampicillin Lenampicillin Metampicillin Talampicillin) Epicillin
Carboxypenicillins (4th generation)	Ticarcillin Carbenicillin / Carindacillin Temocillin
Ureidopenicillins (4th generation)	Piperacillin Azlocillin Mezlocillin
Other	Mecillinam (Pivmecillinam) Sulbenicillin

1st generation	Cefazolin Cefalexin Cefadroxil Cefapirin Cefazedone Cefazaflur Cefradine Cefroxadine Ceftezole Cefaloglycin Cefacetrile Cefalonium Cefaloridine Cefalotin Cefatrizine
2nd generation	Cefaclor Cefprozil Cefuroxime Cefuroxime axetil Cefamandole Cefonicid Ceforanide Cefuzonam Cephamycin (Cefoxitin Cefotetan Cefminox Cefbuperazone Cefmetazole) Carbacephem (Loracarbef)
3rd generation	Cefixime Ceftriaxone Cefotaxime Antipseudomonal (Ceftazidime Cefoperazone) Cefdinir Cefcapene Cefdaloxime Ceftizoxime Cefmenoxime Cefpiramide Cefpodoxime Ceftibuten Cefditoren Cefotiam Cefetamet Cefodizime Cefpimizole Cefsulodin Cefteram Ceftiolene Oxacephem (Flomoxef Latamoxef)
4th generation	Cefepime Cefozopran Cefpirome Cefquinome
5th generation	Ceftaroline fosamil Ceftolozane Ceftobiprole
Siderophore	Cefiderocol
Veterinary	Ceftiofur Cefquinome Cefovecin

Combinations

Lipopeptides	Insert into bacterial cell wall causing perforation. And depolarization: Daptomycin Surfactin
Other	Inhibits PG elongation and crosslinking: Ramoplanin

Intracellular

Inhibit PG subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin)
DADAL/AR inhibitors (Cycloserine)
bactoprenol inhibitors (Bacitracin)

Other

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