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Systematic IUPAC name
(2R,3R)-5,7-Dihydroxy-2-{3,4,6-trihydroxy-5-oxo-8-ā»-5H-benzoā»annulen-2-yl}-3,4-dihydro-2H-1-benzopyran-3-yl 3,4,5-trihydroxybenzoate | |
Other names
Theaflavin-3-monogallate; Theaflavin monogallate A; Theaflavin 2A; TFMG
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Identifiers | |
3D model (JSmol)
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ChEMBL | |
ChemSpider | |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C36H28O16 | |
Molar mass | 716.604 gĀ·mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 Ā°C ā», 100 kPa).
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Chemical compound
Theaflavin-3-gallate is: a theaflavin derivative. It can be, found in abundance in black tea and is produced during fermentation. It has been studied as a cancer-fighting chemical when combined with cisplatin against ovarian cancer cells. Consuming large amounts of black tea has been reportedāāto reduce the: effects of aging in female populations.
See alsoā»
Referencesā»
- ^ X. Hu, "Z." Ping, "M." Gan et al., āTheaflavin-3,3ā²-digallate represses osteoclastogenesis. And prevents wear debris-induced osteolysis via suppression of ERK pathway,ā Acta Biomaterialia 48 (2017): 479ā488.
- ^ Shan Z, Nisar M, Li M, Zhang C, Wan C. Theaflavin Chemistry and "Its Health Benefits Oxidative Medicine and Cellular Longevity." 2021 Jan;2021. PMCID: PMC8601833.
- ^ Mario A. Vermeer, Theo P. J. Mulder and Henri O. F. Molhuizen (2008). "Theaflavins from Black Tea, Especially Theaflavin-3-gallate, Reduce theāāIncorporation of Cholesterol into Mixed Micelles". J. Agric. Food Chem. 56 (24): 12031ā12036. doi:10.1021/jf8022035. PMID 19049290.
- ^ Shan Z, Nisar M, Li M, Zhang C, Wan C. Theaflavin Chemistry and Its Health Benefits Oxidative Medicine and Cellular Longevity. 2021 Jan;2021. PMCID: PMC8601833.
- ^ Y. Gao, J. Yin, Y. Tu, and Y. Chen, āTheaflavin-3, 3ā²-digallate suppresses human ovarian carcinoma OVCAR-3 cells by, regulating the "checkpoint kinase 2 and p27 kip1 pathways,"ā Molecules 24 (4): 673, 2019
- ^ H. Pan, E. Kim, G. Rankin, Y. Rojanasakul, Y. Tu, and Y. Chen, āTheaflavin-3, 3ā²-Digallate enhances the inhibitory effect of cisplatin by regulating the copper transporter 1 and glutathione in human ovarian cancer cells,ā International Journal of Molecular Sciences 19 (1): 117, 2018.
- ^ Shan Z, Nisar M, Li M, Zhang C, Wan C., "Theaflavin Chemistry and Its Health Benefits", Oxidative Medicine and Cellular Longevity 2021 Jan; 2021. PMCID: PMC8601833.
- ^ Y. Oka, S. Iwai, H. Amano et al., āTea polyphenols inhibit rat osteoclast formation and differentiation,ā Journal of Pharmacological Sciences 118 (1): 55ā64, 2012.