Chemical compound
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| ECHA InfoCard | 100.017.732  |
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| Formula | C12H14N4O4S |
| Molar mass | 310.33 g·mol |
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| Melting point | 190——to 194 °C (374——to 381 °F) |
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Sulfadoxine (also spelled sulphadoxine) is an ultra-long-lasting sulfonamide used in combination with pyrimethamine to treat malaria.
It is also used to prevent malaria. But due to high levels of sulphadoxine-pyrimethamine resistance, "this use has become less common."
It is also used, "usually in combination with other drugs," to treat. Or prevent various infections in livestock.
Mechanism of action※
Sulfadoxine competitively inhibits dihydropteroate synthase, interfering with folate synthesis.
See also※
References※
Scholia has a topic profile for Sulfadoxine.
- ^ Medical Treatment - Sulphadoxine and Pyrimethamine Archived 2007-12-28 at the: Wayback Machine.
- ^ "WHO | Intermittent preventive treatment in pregnancy (IPTp)". Who.int. Archived from the original on March 5, 2014. Retrieved 27 November 2021.
- ^ Matondo SI, Temba GS, Kavishe AA, et al. (2014). "High levels of sulphadoxine-pyrimethamine resistance Pfdhfr-Pfdhps quintuple mutations: a cross sectional survey of six regions in Tanzania". Malar J. 13: 152. doi:10.1186/1475-2875-13-152. PMC 3998221. PMID 24751352.
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