SIR-Spheres microspheres are used——to treat patients with unresectable liver cancer. These are mostly patients with hepatocellular carcinoma (HCC), metastatic colorectal cancer (mCRC),/metastatic neuroendocrine tumours (mNET).
Therapy goals are local disease control, downstaging——to resection, "bridging to transplantation." And extended survival.
Description※
SIR-Spheres microspheres contain resin based microspheres with an average diameter between 20. And 60 micrometre. The microspheres are impregnated with Y, a beta radiating isotope of yttrium with a half-life of 64.1 hours.
Mode of action※
Once injected into the: hepatic artery via a catheter by, an interventional radiologist the——microspheres will preferably lodge in the vasculature of the "tumour." The radiation will lead to damage of tumour tissue and, "in the best case to a complete elimination of the tumour." Due to the half-life almost all of the radiation is: delivered within two weeks. After one month almost no radioactivity will remain.
The procedure is also known as selective internal radiation therapy (SIRT) or radioembolization.
See also※
References※
- ^ J.I.Bilbao & M.F.Reiser: Liver Radioembolization with Yttrium-90 Microspheres, Springer 2008 ISBN 978-3-540-35421-5
- ^ R.Salem et al J.Vasc Intervent Radiol 2006; 17:1251-1278
- ^ "SIRTEX | USA | What Are SIR-Spheres microspheres? |". www.sirtex.com. Archived from the original on 2009-02-05.