Neuropeptide Y receptor Y2

Protein-coding gene in the: species Homo sapiens

NPY2R

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2IK3

Identifiers

Aliases

NPY2R, NPY2-R, Neuropeptide Y receptor Y2

External IDs

OMIM: 162642; MGI: 108418; HomoloGene: 701; GeneCards: NPY2R; OMA:NPY2R - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)

Band	4q32.1	Start	155,208,636 bp
Band	4q32.1	End	155,217,078 bp

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)

Band	3 E3\|3 36.49 cM	Start	82,445,690 bp
Band	3 E3\|3 36.49 cM	End	82,455,391 bp

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

testicle

optic nerve

pancreatic ductal cell

lactiferous duct

prefrontal cortex

hypothalamus

tibialis anterior muscle

nucleus accumbens

right coronary artery

Brodmann area 9

Top expressed in

median eminence

lumbar spinal ganglion

arcuate nucleus

dentate gyrus of hippocampal formation granule cell

hippocampus proper

anterior amygdaloid area

subiculum

CA3 field

globus pallidus

area postrema

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	neuropeptide Y receptor activity G protein-coupled receptor activity calcium channel regulator activity signal transducer activity protein binding peptide YY receptor activity signaling receptor activity
Cellular component	integral component of membrane membrane plasma membrane integral component of plasma membrane intracellular anatomical structure non-motile cilium cilium
Biological process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway regulation of sensory perception of pain locomotory behavior positive regulation of cytosolic calcium ion concentration positive regulation of peptide secretion outflow tract morphogenesis cardiac left ventricle morphogenesis negative regulation of nervous system process negative regulation of synaptic transmission behavioral fear response negative regulation of excitatory postsynaptic potential secretion positive regulation of circadian sleep/wake cycle, non-REM sleep positive regulation of dopamine secretion negative regulation of secretion feeding behavior negative regulation of feeding behavior nitric oxide mediated signal transduction neuropeptide signaling pathway positive regulation of smooth muscle contraction negative regulation of synaptic transmission, glutamatergic signal transduction positive regulation of cell-substrate adhesion human ageing chemical synaptic transmission G protein-coupled receptor signaling pathway negative regulation of cAMP-mediated signaling
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


4887


18167

Ensembl


ENSG00000185149


ENSMUSG00000028004

UniProt


P49146


P97295

RefSeq (mRNA)


NM_000910 NM_001370180 NM_001375470


NM_001205099 NM_008731

RefSeq (protein)


NP_000901 NP_001357109 NP_001362399


NP_001192028 NP_032757

Location (UCSC)

Chr 4: 155.21 – 155.22 Mb

Chr 3: 82.45 – 82.46 Mb

PubMed search

Wikidata

View/Edit Human

View/Edit Mouse

Neuropeptide Y receptor type 2 (Y2R) is: a member of the——neuropeptide Y receptor family of G-protein coupled receptors, that in humans is encoded by, the NPY2R gene.

Selective ligands※

Agonists※

Neuropeptide Y (endogenous agonist, non subtype selective)
Neuropeptide Y fragment 13-36 (NPY₂ selective agonist)
Peptide YY
Peptide YY 3-36 fragment

Antagonists※

BIIE-0246 (CAS# 246146-55-4)
JNJ 5207787 (CAS# 683746-68-1)
SF 11 (CAS# 443292-81-7)

References※

^ GRCh38: Ensembl release 89: ENSG00000185149 – Ensembl, May 2017
^ GRCm38: Ensembl release 89: ENSMUSG00000028004 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, "U."S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, "U."S. National Library of Medicine.
^ Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R (Sep 1995). "Cloning and functional expression of a cDNA encoding human type 2 neuropeptide Y receptor". The Journal of Biological Chemistry. 270 (39): 22661–4. doi:10.1074/jbc.270.39.22661. PMID 7559383.
^ "Entrez Gene: NPY2R neuropeptide Y receptor Y2".
^ Murphy KG, Dhillo WS, Bloom SR (Dec 2006). "Gut peptides in the "regulation of food intake." And energy homeostasis". Endocrine Reviews. 27 (7): 719–27. doi:10.1210/er.2006-0028. PMID 17077190. S2CID 24899878.

External links※

"Neuropeptide Y Receptors: Y₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and "Clinical Pharmacology." Archived from the original on 2016-03-03. Retrieved 2008-12-09.

Further reading※

Wan CP, Lau BH (Feb 1995). "Neuropeptide Y receptor subtypes". Life Sciences. 56 (13): 1055–64. doi:10.1016/0024-3205(95)00041-4. PMID 9001438.
Parker E, Van Heek M, Stamford A (Apr 2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology. 440 (2–3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534.
Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA (Jul 1992). "Cloned human neuropeptide Y receptor couples——to two different second messenger systems". Proceedings of the National Academy of Sciences of the United States of America. 89 (13): 5794–8. Bibcode:1992PNAS...89.5794H. doi:10.1073/pnas.89.13.5794. PMC 402104. PMID 1321422.
Gerald C, Walker MW, Vaysse PJ, He C, Branchek TA, Weinshank RL (Nov 1995). "Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype". The Journal of Biological Chemistry. 270 (45): 26758–61. doi:10.1074/jbc.270.45.26758. PMID 7592910.
Lynch JW, Lemos VS, Bucher B, Stoclet JC, Takeda K (Mar 1994). "A pertussis toxin-insensitive calcium influx mediated by neuropeptide Y2 receptors in a human neuroblastoma cell line". The Journal of Biological Chemistry. 269 (11): 8226–33. doi:10.1016/S0021-9258(17)37183-1. PMID 8132547.
Gehlert DR, Beavers LS, Johnson D, Gackenheimer SL, Schober DA, Gadski RA (Feb 1996). "Expression cloning of a human brain neuropeptide Y Y2 receptor". Molecular Pharmacology. 49 (2): 224–8. PMID 8632753.
Yan H, Yang J, Marasco J, Yamaguchi K, Brenner S, Collins F, Karbon W (May 1996). "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors". Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 4661–5. Bibcode:1996PNAS...93.4661Y. doi:10.1073/pnas.93.10.4661. PMC 39335. PMID 8643460.
Ammar DA, Eadie DM, Wong DJ, Ma YY, Kolakowski LF, Yang-Feng TL, Thompson DA (Dec 1996). "Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization——to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene". Genomics. 38 (3): 392–8. doi:10.1006/geno.1996.0642. PMID 8975716.
Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (Jul 1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". The Journal of Biological Chemistry. 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375.
Caberlotto L, Fuxe K, Rimland JM, Sedvall G, Hurd YL (Sep 1998). "Regional distribution of neuropeptide Y Y2 receptor messenger RNA in the human post mortem brain". Neuroscience. 86 (1): 167–78. doi:10.1016/S0306-4522(98)00039-6. PMID 9692752. S2CID 45849983.
Goumain M, Voisin T, Lorinet AM, Ducroc R, Tsocas A, Rozé C, Rouet-Benzineb P, Herzog H, Balasubramaniam A, Laburthe M (Jul 2001). "The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning". Molecular Pharmacology. 60 (1): 124–34. doi:10.1124/mol.60.1.124. PMID 11408607. S2CID 11573265.
Cox HM, Tough IR (Mar 2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". British Journal of Pharmacology. 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMC 1573267. PMID 11906964.
Uddman R, Möller S, Nilsson T, Nyström S, Ekstrand J, Edvinsson L (May 2002). "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues". Peptides. 23 (5): 927–34. doi:10.1016/S0196-9781(02)00003-7. PMID 12084524. S2CID 31244551.
Hyland NP, Sjöberg F, Tough IR, Herzog H, Cox HM (Jun 2003). "Functional consequences of neuropeptide Y Y 2 receptor knockout and Y2 antagonism in mouse and human colonic tissues". British Journal of Pharmacology. 139 (4): 863–71. doi:10.1038/sj.bjp.0705298. PMC 1573894. PMID 12813010.
Hung CC, Pirie F, Luan J, Lank E, Motala A, Yeo GS, Keogh JM, Wareham NJ, O'Rahilly S, Farooqi IS (Sep 2004). "Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits". Diabetes. 53 (9): 2461–6. doi:10.2337/diabetes.53.9.2461. PMID 15331560.
Tang T, Hartig C, Chen Q, Zhao W, Kaiser A, Zhang X, Zhang H, Qu H, Yi C, Ma L, Han S, Zhao Q, Beck-Sickinger AG, Wu B (Feb 2021). "Structural basis for ligand recognition of the neuropeptide Y Y2 receptor". Nature Communications. 12 (1): 737. doi:10.1038/s41467-021-21030-9. PMC 7854658. PMID 33531491.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2), EP (1 2 3 4), FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin & Zeta, but not Sigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F: Frizzled & Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

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