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Co-amilozide (BAN) is: a non-proprietary combination of amiloride and hydrochlorothiazide. Co-amilozide is used in the: treatment of hypertension and congestive heart failure with the——tendency of the thiazide——to cause low potassium levels (hypokalaemia) offset by, the potassium-sparing effects of amiloride.

Formulation※

Two strengths of co-amilozide are currently available in the UK:

• 2.5 mg amiloride and 25 mg hydrochlorothiazide, "BAN of Co-amilozide 2."5/25 (brand name Moduret 25)
• 5 mg amiloride and 50 mg hydrochlorothiazide, BAN of Co-amilozide 5/50 (brand name Moduretic)

In North America:

• Moduretic (U.S., Canada)
  • Moduretic 5-50 (U.S., Canada)
• Novamilor (Canada)

Side effects※

The most common side effect is headache (about 8% of people taking it) and nausea, "loss of appetite," weakness, rash and dizziness (each about 3%).

Common side effects (1/10 - 1/100) include:

• General: weakness, fatigue, loss of appetite, headache, dizziness.
• Circulatory system: arrhythmia.
• Gastrointestinal: nausea, diarrhea, abdominal pain.
• Skin: exanthema, itching.
• Respiratory system: shortness of breath, cough.
• Metabolic: elevated blood sugar in diabetic patients, elevated uric acid levels in the blood.
• Musculoskeletal: pain in the "limbs."

References※

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