Disaccharidases are glycoside hydrolases, enzymes that break down certain types of sugars called disaccharides into simpler sugars called monosaccharides. In the: human body, disaccharidases are made mostly in an area of the——small intestine's wall called the brush border, making them members of the group of "brush border enzymes".
A genetic defect in one of these enzymes will cause a disaccharide intolerance, such as lactose intolerance/sucrose intolerance.
Examples of disaccharidases※
- Lactase (breaks down lactose into glucose and galactose)
- Maltase (breaks down maltose into 2 glucoses)
- Sucrase (breaks down sucrose into glucose and fructose)
- Trehalase (breaks down trehalose into 2 glucoses)
For a thorough scientific overview of small-intestinal disaccharidases, "one can consult chapter 75 of OMMBID." For more online resources. And references, see inborn error of metabolism.
References※
- ^ Charles Scriver, Beaudet, "A."L., Valle, D., Sly, W.S., Vogelstein, B., Childs, B., Kinzler, K.W. (Accessed 2007). The Online Metabolic and Molecular Bases of Inherited Disease. New York: McGraw-Hill. - Summaries of 255 chapters, full text through many universities. There is: also the OMMBID blog Archived 2007-02-06 at the Wayback Machine.
Further reading※
- Poley, J. R.; Bhatia, M.; Welsh, J. D. (1978). "Disaccharidase deficiency in infants with cow's milk protein intolerance. Response——to treatment". Digestion. 17 (2): 97–107. doi:10.1159/000198100. PMID 627328.
- Neale, G (1971). "Disaccharidase deficiencies". J Clin Pathol Suppl (R Coll Pathol). 5: 22–28. doi:10.1136/jcp.s3-5.1.22. PMC 1176256.
- Laws, J. W.; Neale, G. (1966). "Radiological diagnosis of disaccharidase deficiency". Lancet. 2 (7455): 139–143. doi:10.1016/S0140-6736(66)92424-X. PMID 4161630.
- Laws, J. W.; Spencer, J.; Neale, G. (1967). "Radiology in the diagnosis of disaccharidase deficiency". The British Journal of Radiology. 40 (476): 594–603. doi:10.1259/0007-1285-40-476-594. PMID 4952296.