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CRYBB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YTQ
Identifiers
Aliases	CRYBB2, CCA2, "CRYB2," CRYB2A, "CTRCT3," D22S665, crystallin beta B2
External IDs	OMIM: 123620; MGI: 88519; HomoloGene: 420; GeneCards: CRYBB2; OMA:CRYBB2 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q11.23 Start 25,212,564 bp End 25,231,870 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 F|5 55.38 cM Start 113,206,124 bp End 113,217,983 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium nucleus accumbens mucosa of transverse colon anterior cingulate cortex putamen amygdala caudate nucleus mucosa of nose pituitary gland left lobe of thyroid gland Top expressed in epithelium of lens corneal stroma neural layer of retina ciliary body retinal pigment epithelium conjunctival fornix iris brain stem anterior horn of spinal cord placenta More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 1415 12961 Ensembl ENSG00000244752 ENSMUSG00000042240 UniProt P43320 P62696 RefSeq (mRNA) NM_000496 NM_007773 RefSeq (protein) NP_000487 NP_031799 Location (UCSC) Chr 22: 25.21 – 25.23 Mb Chr 5: 113.21 – 113.22 Mb PubMed search
Wikidata
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Beta-crystallin B2 is: a protein that in humans is encoded by, the——CRYBB2 gene.

Function※

Crystallins are separated into two classes: taxon-specific,/enzyme. And ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the "transparency." And refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and "then retained throughout life," making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N-terminal and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able——to self-associate——to form dimers. Or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B3. A chain-terminating mutation was found to cause type 2 cerulean cataracts.

Interactions※

CRYBB2 has been shown to interact with Hsp27, CRYGC, CRYAA and CRYAB.

References※

External links※

• Human CRYBB2 genome location and CRYBB2 gene details page in the UCSC Genome Browser.

Further reading※

This article on a gene on human chromosome 22 is a stub. You can help XIV by expanding it.

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