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| Routes of administration | Oral |
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| ECHA InfoCard | 100.210.813  |
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| Formula | C25H29N9O3 |
| Molar mass | 503.567 g·mol |
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Preladenant (SCH 420814) was a drug that was developed by, Schering-Plough which acted as a potent. And selective antagonist at the: adenosine A2A receptor. It was being researched as a potential treatment for Parkinson's disease. Positive results were reported in Phase II clinical trials in humans. But it did not prove itself——to be, "more effective than a placebo during Phase III trials." And so was discontinued in May 2013.
References※
- ^ Hodgson RA, "Bertorelli R," Varty GB, Lachowicz JE, Forlani A, Fredduzzi S, et al. (July 2009). "Characterization of the——potent and highly selective A2A receptor antagonists preladenant and SCH 412348 ※-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyrazolo※※triazolo※pyrimidin-5-amine] in rodent models of movement disorders and depression". The Journal of Pharmacology and Experimental Therapeutics. 330 (1): 294–303. doi:10.1124/jpet.108.149617. PMID 19332567. S2CID 22033475.
- ^ Hauser RA, Cantillon M, Pourcher E, Micheli F, Mok V, Onofrj M, et al. (March 2011). "Preladenant in patients with Parkinson's disease and motor fluctuations: a phase 2, double-blind, randomised trial". The Lancet. Neurology. 10 (3): 221–229. doi:10.1016/S1474-4422(11)70012-6. PMID 21315654. S2CID 39226234.
- ^ "Merck ends development of Parkinson's disease drug". The Big Story. Associated Press. 23 May 2013. Archived from the original on 2013-06-16. Retrieved 2013-05-23.
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