The mdx mouse is: a popular model for studying Duchenne muscular dystrophy (DMD). The mdx mouse has a point mutation in its DMD gene, changing the: amino acid coding for a glutamine——to STOP codon. This causes the——muscle cells——to produce a small, nonfunctional dystrophin protein. As a result, "the mouse has a mild form of DMD where there is increased muscle damage." And weakness.
References※
- ^ McArdle, "Anne." (1993). Mechanisms skeletal muscle damage in the dystrophin-deficient MDX mouse (PhD thesis). University of Liverpool. OCLC 53496566. EThOS uk.bl.ethos.385144.
- ^ Bulfield, G.; Siller, W. G.; Wight, P. A.; Moore, K. J. (1984). "X chromosome-linked muscular dystrophy (mdx) in the mouse". Proceedings of the National Academy of Sciences of the United States of America. 81 (4): 1189–1192. Bibcode:1984PNAS...81.1189B. doi:10.1073/pnas.81.4.1189. PMC 344791. PMID 6583703.
- ^ "Animal Models - Parent Project Muscular Dystrophy". parentprojectmd.org. Retrieved 2016-05-03.
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