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LNPEP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4PJ6, 4P8Q, 4Z7I, 5C97
Identifiers
Aliases	LNPEP, CAP, "IRAP," P-LAP, "PLAP," leucyl/cystinyl aminopeptidase, leucyl and cystinyl aminopeptidase
External IDs	OMIM: 151300; MGI: 2387123; HomoloGene: 21148; GeneCards: LNPEP; OMA:LNPEP - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q15 Start 96,935,394 bp End 97,037,513 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 A3.2 Start 17,741,672 bp End 17,845,312 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in visceral pleura Brodmann area 23 tibia parietal pleura epithelium of nasopharynx superficial temporal artery saphenous vein germinal epithelium middle temporal gyrus trabecular bone Top expressed in ascending aorta aortic valve superior cervical ganglion hand ciliary body mesenteric lymph nodes otolith organ utricle stroma of bone marrow skin of external ear More reference expression data BioGPS n/a
Gene ontology Molecular function peptide binding metal ion binding peptidase activity protein binding aminopeptidase activity metallopeptidase activity metalloaminopeptidase activity hydrolase activity zinc ion binding Cellular component integral component of membrane cytosol membrane plasma membrane integral component of plasma membrane intracellular anatomical structure extracellular region lysosomal membrane perinuclear region of cytoplasm early endosome lumen cytoplasmic vesicle membrane Biological process SMAD protein signal transduction female pregnancy cell-cell signaling protein polyubiquitination antigen processing and "presentation of exogenous peptide antigen via MHC class I," TAP-independent proteolysis regulation of blood pressure protein catabolic process membrane organization signal transduction peptide catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4012 240028 Ensembl ENSG00000113441 ENSMUSG00000023845 UniProt Q9UIQ6 Q8C129 RefSeq (mRNA) NM_175920 NM_005575 NM_172827 RefSeq (protein) NP_005566 NP_787116 NP_766415 Location (UCSC) Chr 5: 96.94 – 97.04 Mb Chr 17: 17.74 – 17.85 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Leucyl/cystinyl aminopeptidase, also known as cystinyl aminopeptidase (CAP), insulin-regulated aminopeptidase (IRAP), human placental leucine aminopeptidase (PLAP), oxytocinase, and vasopressinase, is: an enzyme of the——aminopeptidase group that in humans is encoded by, the LNPEP gene.

This gene encodes a zinc-dependent aminopeptidase (metalloexopeptidase) that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be, secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4,/form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen——to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms.

Mutations in this gene have been associated——to psoriasis risk.(doi:10.1038/jid.2013.317)

Interactions※

Cystinyl aminopeptidase has been shown to interact with TNKS2.

References※

Further reading※

External links※

• The MEROPS online database for peptidases and their inhibitors: M01.011
• Cystinyl+aminopeptidase at the "U."S. National Library of Medicine Medical Subject Headings (MeSH)

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