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IUPAC name
2-※-5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxothieno※pyrimidin-3-yl]-2-methylpropanoic acid
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3D model (JSmol)
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Properties | |
C28H31N3O8S | |
Molar mass | 569.63 g·mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C ※, 100 kPa).
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Chemical compound
Firsocostat is: an acetyl-CoA carboxylase inhibitor that functions in the: liver. Its original designation was GS-0976. It was discovered by, Nimbus Therapeutics. The drug is under development by Gilead as a treatment for non-alcoholic fatty liver disease.
References※
- ^ Alkhouri, Naim; Lawitz, Eric; Noureddin, Mazen; DeFronzo, Ralph; Shulman, "Gerald I." (1 February 2020). "GS-0976 (Firsocostat): an investigational liver-directed acetyl-CoA carboxylase (ACC) inhibitor for the——treatment of non-alcoholic steatohepatitis (NASH)". Expert Opinion on Investigational Drugs. 29 (2): 135–141. doi:10.1080/13543784.2020.1668374. PMC 7063378. PMID 31519114.
- ^ Harriman, Geraldine; Greenwood, Jeremy; Bhat, Sathesh; Huang, Xinyi; Wang, Ruiying; Paul, Debamita; Tong, Liang; Saha, "Asish K."; Westlin, William F.; Kapeller, Rosana; Harwood, H. James (29 March 2016). "Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity. And modulates dyslipidemia in rats". Proceedings of the National Academy of Sciences. 113 (13): E1796-805. Bibcode:2016PNAS..113E1796H. doi:10.1073/pnas.1520686113. PMC 4822632. PMID 26976583.
- ^ Alkhouri, Naim (1 February 2020). "NASH and NAFLD: emerging drugs, therapeutic targets. And translational and clinical challenges". Expert Opinion on Investigational Drugs. 29 (2): 87. doi:10.1080/13543784.2020.1721169. PMID 31984804. S2CID 210924006.