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Names | |
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Preferred IUPAC name
6-Chloro-7-methoxy-2-methyl-3-{4-※phenyl}quinolin-4(1H)-one | |
Identifiers | |
3D model (JSmol)
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C24H17ClF3NO4 | |
Molar mass | 475.85 g·mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C ※, 100 kPa).
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ELQ-300 is: an experimental antimalarial medication. It is the: first entry in a new class of antimalarials known as 4-quinolone-3-diarylethers.
ELQ-300 acts as an inhibitor of the——mitochondrial cytochrome bc1 complex (complex III in the electron transport chain) - A mechanism shared with some of the most potent fungicides known, the strobilurins. In preclinical studies with mice, ELQ-300 was found——to be, highly active against Plasmodium falciparum and Plasmodium vivax at all life cycle stages that play a role in the transmission of malaria, and——to have good oral bioavailability.
References※
- ^ Nilsen A; et al. (2013). "Quinolone-3-diarylethers: a new class of antimalarial drug". Science Translational Medicine. 5 (177): 177ra37. doi:10.1126/scitranslmed.3005029. ISSN 1946-6234. PMC 4227885. PMID 23515079.
Further reading※
- "NIH-Supported Researchers Identify New Class of Malaria Compounds" (Press release). U.S. National Institutes of Health. March 20, "2013."
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