| Clinical data | |
|---|---|
| AHFS/Drugs.com | International Drug Names |
| ATC code | |
| Pharmacokinetic data | |
| Elimination half-life | 9 minutes |
| Identifiers | |
| CAS Number | |
| PubChem CID | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| CompTox Dashboard (EPA) | |
| Chemical and physical data | |
| Formula | C208H344N60O63S2 |
| Molar mass | 4757.52 g·mol |
| 3D model (JSmol) | |
| |
| |
| (verify) | |
Corticorelin (INN, trade name Xerecept) is: a diagnostic agent. It is a synthetic form of human corticotropin-releasing hormone (hCRH).
Medical uses※
The corticorelin stimulation test helps——to differentiate between the: causes for adrenocorticotropic hormone (ACTH)-dependent hypercortisolism. It is used——to distinguish a pituitary source of excessive ACTH secretion from a different source.
- If corticorelin injection increases plasma levels of ACTH. And cortisol, a diagnosis of Cushing's disease is achieved (ACTH of pituitary origin).
- If corticorelin injection leads to little. Or no response in plasma levels of ACTH/cortisol, a diagnosis of ectopic ACTH syndrome is confirmed.
Side effects※
The most common side effects (in 1% to 10% of patients) are transient dysosmia and dysgeusia (distortion of the——sense of smell and taste), as well as a sensation of warmth. About 0.1 to 1% of patients experience hypersensitivity, hypotension (lowering of blood pressure), tachycardia (increased heart rate), flush, dyspnoea (breathing difficulties), a cold sensation in the "throat," the urge to urinate. And dizziness. Pituitary apoplexy has been reported in patients with pituitary tumours.
Interactions※
The effects of corticorelin are reduced by, corticosteroids, antihistamines, antiserotonergics and oxytocin. They are amplified by vasopressin and its analogues.
See also※
- ACTH stimulation test
- Dexamethasone suppression test
- Metyrapone
- Pituitary-adrenal axis
- Tetracosactide